Boluoke® (lumbrokinase) is the only fully researched oral enzyme on the market supporting a healthier blood state, and it shows great promise in supporting a healthy coagulation/fibrinolysis balance in the body.  Coagulation system is a complicated and highly regulated system. Modern lifestyles often tip the balance towards hypercoagulation (thick blood) and rarely towards hypocoagulation.  For most people, Boluoke® can support the body in keeping the system in a more balanced state.

Lumbrokinase is a more potent enzyme preparation than nattokinase. One of the advantages of Boluoke® (lumbrokinase) is that it does not interfere with the clotting cascade, but instead, works by reducing fibrinogen and fibrin. Boluoke® does not affect INR or aPTT, thus is compatible with Coumadin® or heparin.

Boluoke® vs. Other Lumbrokinase Products
Comparing other lumbrokinase products to Boluoke® is like comparing apples and oranges. Boluoke®’s enzymatic strength is standardized against urokinase and t-PA. The imitation products are likely just earthworm protein extract containing little pure lumbrokinase or lumbrokinase of low enzymatic strength. Some companies are making products with 230mg to 250mg of lumbrokinase per capsule and trying to quote Boluoke®’s research as their own. Boluoke®’s capsules are of 200mg in size, and contain 20mg of lumbrokinase inside each capsule. Most of these other lumbrokinase are unable to distinguish between the weight of the capsule (i.e. 250 mg) and the active lumbrokinase per capsule (Boluoke® is 20 mg).

Boluoke® is the only fully researched oral fibrinolytic supplement on the market. Besides having in vitro studies, animal studies, toxicity studies, and pharmacokinetic studies done, Boluoke® has also been put through all phases of clinical trials (including randomized double blind controlled studies) in China. Boluoke® is the only Lumbrokinase that is backed by Phase I – III clinical trials in China, the one that is first used in hospitals in China, and covered by the Chinese National Fundamental Health Insurance.

A common question we receive is about potential side effects of Boluoke®. The earthworm has been used in Traditional Chinese Medicine for a few thousand years, and is considered to be one of the safest medicines in the traditional pharmacopoeias. In one of the largest clinic trials of Boluoke® involving 16 hospitals and 1560 patients in China, the overall adverse reaction rate was 1.92% (30 cases). 0.58% had skin itching, 0.19% had skin rash, and 1.15% had nausea or diarrhea; no hemorrhage or major side effect was reported. Again, this research pertains only to Boluoke®.

It is interesting that other lumbrokinase products cite the clinical results achieved with only Boluoke®, confusing the reader into assuming that the research was done on their formulations. However, their products may be very different, and your patients may have very different results.

On the raw material market, the price of lumbrokinase can vary by up to 15 fold, and the enzymatic strengths of various Lumbrokinase also differ greatly. In addition, lumbrokinase is a preparation containing multiple enzyme fractions, and the extraction and purification method determines the composition of the various enzyme fractions. Thus different extraction methods will produce different sub-fractions of lumbrokinase. This is the reason why Boluoke® does not significantly change prothrombin time (PT) or activated partial thromboplastin time (aPTT), while other lumbrokinase sources may significantly alter PT or aPTT as shown in studies. No other lumbrokinase product can provide you with this assurance.

Enhancing vascular health and addressing the challenges of aging represent critical healthcare priorities worldwide. The foundation of healthy aging hinges upon maintaining robust arterial function and a strong, resilient heart. Introducing Cardio NAD+ 2.0: an advanced solution crafted with cutting-edge ingredients aimed at optimizing cardiovascular well-being. Meticulously formulated to synergistically target various aspects of heart health, this groundbreaking blend underscores the crucial interplay between NAD+ and cardiac vitality, showcasing potent cardioprotective effects.

Featured Supportive Benefits: 

• Improves net NAD+ status by supporting both its synthesis and limiting its degradation 
• Supports healthy blood pressure 
• Improves vascular aging, endothelial function and glycocalyx health
• Supports healthy fibrinolytic activity and clotting function
• Promotes healthy circulation and blood flow 
• Inhibits platelet & red blood cell aggregation
• Decreases blood viscosity
• Supports clinical measures of inflammation 
• Supports healthy levels of nitric oxide
• Inhibits lipid peroxidation
• Supports healthy lipid metabolism
• Demonstrated reduction in various independent cardiovascular risk factors

Balance your immune system with the resilience of nature.

Extracted at low temperature from cod and salmon line-caught in the pristine waters of Alaska, our fish oil delivers essential omega-3 fatty acids and pro-resolving mediators (PRMs). These powerful substances support the body’s immune response for improved mood, cognition, and healthspan.*

• More balanced immune response*
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• Support for heart & cardiovascular health*

Arterosil HP® is the world’s premier supplement to support the endothelial glycocalyx,* the fragile inner lining of the entire vascular system. Arterosil HP contributes to healthy vascular function in multiple ways:*

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Power your cells to support heart and blood vessel health

It is now possible to revitalize each of the 37 trillion cells in your body.

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• Delivers targeted CoQ10 antioxidant support to your mitochondria - the power plants of your cells - to help your organs perform at their best.
• Breakthrough wellness technology that is absorbed by your mitochondria hundreds of times more effectively than regular CoQ10 supplements.
• Supports our natural ability to combat the harmful effects of free radicals and the damage they can cause to our bodies.

Spotlight Ingredients

MitoQ®

• MitoQ® is a shortened form of the antioxidant ubiquinol (a CoQ10) with the addition of an ion called Triphenylphosphonium, which gives it a positive charge.
• These two modifications enable MitoQ® to pass through the mitochondrial membrane, where it provides a payload of free radical defense and helps optimize the energy production process.

L-Carnitine

• Helps the body convert fuel to energy by transporting fatty acids across mitochondrial membranes.

Magnesium

• Magnesium is a crucial component of the enzymes that drive many important cellular energy production processes.

Vitamin D3

• Studies show that normal Vitamin D levels are consistent with a healthy cardiovascular system.

Our Nitric Oxide Indicator Strips, developed at the University of Texas Health Science Center, capture a simple, and non-invasive, saliva sample to determine the concentration of a salivary nitrite, a key biomarker, needed for the production and availability of Nitric Oxide. 

• Non-invasive 
• Instant results 
• Easy to read 
• Each tube contains 25 indicator strips 

Magnesium Glycinate Complex contains highly absorbable magnesium with each capsule providing 150 mg of elemental magnesium. This product should not cause any of the unfavorable gastrointestinal (GI) symptoms associated with magnesium supplementation due to the very stable chelate formed between two glycine molecules and each magnesium ion via a patented process.

Promotes cardiovascular health and helps maintain cholesterol levels already within normal range

• Promotes healthy lipid metabolism
• Enhances bile acid secretion
• Supports liver function
• Promotes prostate health

Patient One Phytosterol Complex supplies plant sterols to promote healthy heart and prostate function. Beta-sitosterol, the most abundant plant sterols, also contains Campesterol and Stigmasterol for additional health benefits. 

Phytosterols are sterol molecules, structurally similar to cholesterol, which are synthesized by plants and are naturally found in grains, nuts, seeds, fruits and vegetable oils. Typical Western diets provide a low amount of phytosterols--only about 100-200 mg per day (based on beta sitosterol content), in sharp contrast to vegetarian and Japanese diets that contain 345 and 400 mg/day, respectively. Further, natural phytosterols are often removed from vegetable oils during processing, pointing toward supplementation as an effective way to receive these healthy molecules.

Studied for more than 50 years, clinical trials suggest that phytosterols provide statistically significant support for healthy lipid metabolism. When plant sterols travel through the digestive tract, they get in the way of dietary cholesterol (from food such as meat and eggs) being absorbed into the bloodstream. Therefore, less total cholesterol is absorbed by the body when plant sterols are present. Plant sterols are believed to block absorption of cholesterol in the intestines while promoting healthy production of bile, offering dual-action support for balanced cholesterol levels. Phytosterols support liver receptor function and maintain healthy enzyme activity.

Beta-sitosterol also promotes healthy prostate function. Research suggests phytosterols naturally bind to prostate tissues, where they exert inflammation-modulating activity and influence cell signaling to help promote normal cell growth in the prostate. Phytosterols have been proposed to modulate testosterone; high intakes may also inhibit 5-alpha-reductase enzyme. Clinical trials also demonstrate the role of phytosterols in healthy urinary function. In a 6-month randomized, double-blind, placebo-controlled, multicenter study with 200 male subjects, it was shown that a mixed phytosterol complex providing beta-sitosterol supported healthy urinary flow. This was also supported in additional studies.

This exclusive formula is designed to support the balance and absorption of fat-soluble vitamins in the body. Help protect your bones, heart, immune health and much more with Protect+.*

This unique, high-potency formula features: 

• 300mcg of a double micro-encapsulated bioactive all-trans K2VITAL Delta MK-7  
• 125 mcg (5,000 IU) of vitamin D3 
• Efficacious amounts of vitamin A and vitamin E  
• AstraGin (astragalus membranaceus and panax notoginseng) to promote maximum absorption and delivery of fat soluble vitamins in the body  

As the science of longevity continues to evolve, more and more researchers are focusing on geroprotectors- compounds capable to have the potential to prevent or even reverse aging at the cellular level. Telomere Prime reflects edge science, featuring a broad spectrum of ingredients that have been shown to support healthy cellular function. The health of our cells is foundational to our overall health, so supporting their health and vitality is one of the smartest things we can do for our long-term wellbeing. The compounds in Telomere Prime have been carefully chosen for their ability to protect and repair DNA, reduce telomere shortening and support healthy cellular function. Telomere Prime supports genomic stability and other key indicators of healthspan and lifespan such as, antioxidant protection, body global cell health, inflammation support, and mitochondrial function.

Featured Benefits:

• Support the body’s natural ability to repair its own DNA.
• Significantly increases telomere length in yearlong clinical trials.
• Inhibit synthesis of pro-inflammatory "inflammaging" cytokines such as interleukin (IL)-6, (IL)-8, NF-KB and TNF-alpha.
• Prevent cell death through inhibition of the pro-apoptotic factors.
• Support your DNA’s defenses against free radical damage and activates NRF2
• Activates the cell and mitochondrial renewal process
• Chelate divalent metal ions.
• Protect against damage caused by the prooxidants ferric-NTA and β-amyloid.
• Enhance the immune system by increasing the life cycle of white blood cells.
• Helps reduce DNA and mitochondrial damage and protect against free radicals.
• Protect against UV and gamma radiation by neutralizing radiation-induced reactive oxygen species (ROS).

Vascanox HP® is a breakthrough product providing nitric oxide support for up to 24 hours with a single dose.*† Vascanox HP supports the natural production, storage, and release of nitric oxide.* Each 60-capsule bottle is a 1-month supply at recommended dosing levels.